Killing Bacteria Using Conjugatively Delivered CRISPR-Cas Systems
Using CRISPR-Cas systems we are able to specifically target pathogenic strains of bacteria.
The plasmid containing our CRISPR-Cas system is delivered to the target bacteria via bacterial conjugation from a commensal bacterial chassis.
Bacterial conjugation is very difficult for bacteria to develop resistance to, and has better penetration than antibiotics under biofilm conditions.
CRISPR-Cas Mediated Cell Death
The guide RNAs on the delivered plasmid encode for specific regions of the bacterial genome that are unique to the pathogen.
Once expressed, the CRISPR-Cas system kills the target bacterial cell by creating double stranded DNA cuts at the target sites of the bacterial genome.
Double stranded DNA cuts are very difficult for bacteria to repair, so the target bacterial cell is unable to survive the damage to it's DNA.
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